RIVER: Towards an HIV cure, kick & kill approach скачать в хорошем качестве

RIVER: Towards an HIV cure, kick & kill approach

In most patients with HIV, the only way to have an undetectable viral load is to take ART every day. If ART is stopped, HIV will become detectable again. The reason for this is that ART only works against HIV that is in awake and active immune cells. However, most immune cells are resting or ‘asleep’ and some of these cells contain HIV. These cells, which are hidden from ART, are called the HIV reservoir. The RIVER study is testing a new way to reduce the size of the HIV reservoir, using an approach called “kick and kill”. Vorinostat, a HDAC inhibitor, is the “kick” and the boosted immune response is the “kill”.