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The word edema comes from the Greek word oidema which means swelling. Edema is presence of increased fluid in the interstitial tissue spaces or an accumulation of fluid in the body cavities in excessive amount. Depending on the site, fluid accumulation in body cavities can be variously designated as: a) Hydrothorax – fluid accumulation in pleural cavity in a pathologic amount. b) Hydropericardium – pathologic amount of fluid accumulated in the pericardial cavity. c) Hydroperitonium (ascites) – fluid accumulation in peritoneal cavity. d) Ancsarca – is a severe & generalized edema of the body with profound subcutaneous swelling. Edema formation is determined by the following factors: 1) Hydrostatic pressure 2) Oncotic pressure 3) Vascular permeability 4) Lymphatic channels 5) Sodium and water retention Edema is easily recognized grossly; microscopically, it is appreciated as clearing and separation of the extracellular matrix and subtle cell swelling