Study Organic Chemistry with Lluís: Total Synthesis of Vilmoraconitine скачать в хорошем качестве

Study Organic Chemistry with Lluís: Total Synthesis of Vilmoraconitine

I describe the Total Synthesis of Vilmoraconitine, a natural product that presents one of the most complex skeleton types in the C19-diterpenoid alkaloids. The molecule features an unprecedented heptacyclic core possessing a rigid cyclopropane unit. Some of the key steps include: 1. An oxidative dearomatization/Diels–Alder cycloaddition. 2. A hydrodealkenylative fragmentation/Mannich reaction. 3. A Robinson annulation. 4. An intramolecular Diels–Alder cycloaddition with an unusual regioselectivity. Reference: J. Am. Chem. Soc. 2023, 145, 3903−3908. The Chemists' Cookbook: https://nrochemistry.com/the-chemists... This essential reference book arranges reactions alphabetically and by type, highlighting target molecules, reaction conditions, isomer ratios, reported yields, references to source articles, and experimental procedures. Additional notes discuss the practical scope and utility of each reaction, covering modifications, intermediate structures, and, in some cases, reaction mechanisms. These entries not only demonstrate the chemistry involved but also clarify its real-world applications, making it an invaluable resource for chemists at every level. The Chemists' Cookbook includes an introduction by Professor Erick Carreira and a foreword by Professor Phil Baran, underscoring its significance to the field of synthetic organic chemistry. Amazon.com: https://a.co/d/7LAj0HR The Chemists’ Cookbook paperback is available for purchase on the following Amazon’s marketplaces: US, UK, CA, DE, FR, ES, IT, NL, PL, and SE. Please check your nearest marketplace to verify whether a delivery to your country is possible.