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Inflammatory breast cancer (IBC) is rare but highly aggressive, and often hides in plain sight. Rather than presenting as the distinct lump, IBC typically appears as redness or swelling in the breast and skin changes that can mimic mastitis or infection, leading to dangerous delays in diagnosis. In this episode of BackTable Tumor Board, breast medical oncologists Dr. Lindsay Peterson and Dr. Bora Lim break down how to recognize IBC’s typical and atypical presentations, approach diagnostic workup, and tailor treatment across subtypes. --- SYNPOSIS Dr. Peterson and Dr. Lim explore evolving neoadjuvant strategies, emerging clinical trials, combination therapies, IBC vaccine development, and the growing role of AI and MRI pattern recognition in predicting recurrence and guiding surveillance. The discussion highlights the importance of multidisciplinary expertise and calls for broader clinician awareness–especially in primary care, dermatology, and urgent care–so that persistent “infection-like” breast changes prompt timely evaluation and treatment for IBC. --- TIMESTAMPS 0:00 - Introduction 3:26 - Typical Presentations of Inflammatory Breast Cancer (IBC) 8:30 - Atypical Presentations of IBC 11:48 - Routine Diagnostic Workup 16:06 - Treatments for Different Subtypes of IBC 19:49 - Clinical Trials 22:53 - Surveillance for Different Stages of IBC 25:59 - Current Clinical Trials for Best Treatments 29:18 - Central Nervous System Recurrence and Other Relapse Patterns in IBC 33:29 - Novel Neoadjuvant Therapy 37:27 - Centers Dedicated to Treating IBC 42:13 - Final Thoughts --- RESOURCES Atezolizumab, Cobimetinib, and Eribulin in Treating Patients With Chemotherapy Resistant Metastatic Inflammatory Breast Cancer https://clinicaltrials.gov/study/NCT0... Dana-Farber Cancer Institute https://www.dana-farber.org/cancer-ca... MD Anderson Inflammatory Breast Cancer Clinic https://www.mdanderson.org/patients-f... --- BackTable Tumor Board is a multidisciplinary podcast for healthcare professionals that play an active role in cancer care. #ONC49 #breastcancer #oncology #medicaloncology