1. Glucocorticoids & Calcineurin Inhibitors: Immunomodulators: Pharmacology скачать в хорошем качестве

1. Glucocorticoids & Calcineurin Inhibitors: Immunomodulators: Pharmacology

𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩‍⚕‍ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊 📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺 :   / clinical.learning   1. Glucocorticoids & Calcineurin Inhibitors: Immunomodulators ------------------------------------------------------------------------------------------------------- Glucocorticoids and calcineurin inhibitors are potent immunomodulators used to suppress the immune system 🛡️, making them essential in the management of autoimmune diseases, organ transplantation, and inflammatory disorders 🩺💊. 🔹 Glucocorticoids (Prednisone, Dexamethasone, Methylprednisolone) 💉 Act by binding to intracellular glucocorticoid receptors (GRs) 🧬, leading to inhibition of pro-inflammatory genes (NF-κB) and upregulation of anti-inflammatory mediators. Decrease cytokine production, lymphocyte proliferation, and macrophage activation, effectively suppressing inflammation and immune responses. Used in rheumatoid arthritis (RA) 🤲, asthma 🌬️, inflammatory bowel disease (IBD) 🏥, and transplant rejection prevention. Long-term use can cause Cushing’s syndrome (moon face, buffalo hump 🐃), osteoporosis 🦴, hyperglycemia 🍬, and adrenal suppression. 🔹 Calcineurin Inhibitors (Cyclosporine & Tacrolimus) 🚫🧬 Block calcineurin, preventing activation of T-cell transcription factors (NFAT) that regulate IL-2 production, a key cytokine for T-cell proliferation. Used primarily in organ transplantation 🏥, psoriasis, atopic dermatitis, and autoimmune disorders. Cyclosporine is associated with nephrotoxicity 🚨, hypertension 🩺, hirsutism 🧔, while Tacrolimus has a higher risk of diabetes 🍬. Both drug classes effectively prevent immune system overactivity but require careful monitoring to balance immunosuppression with infection risk 🦠. 🌿✨ #Glucocorticoids 💊 #CalcineurinInhibitors #Immunosuppression 🛡️ #TransplantDrugs 🏥 #AutoimmuneTreatment #InflammationControl 🔥 #MedicalEducation 📚 #MBBSNotes #StudySmart 🧠 #SteroidTherapy #Tacrolimus #Cyclosporine #SafeImmunosuppression #CytokineInhibition