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CRISPR is a powerful gene editing tool, but its uses have been purely scientific until now. In 2023, US and UK drug regulators including the FDA approved Casgevy, a CRISPR/Cas9-based therapy for sickle cell disease and beta-thalassemia. The FDA also approved a similar treatment, Lyfgenia. Here's how they work. Hosted by: Reid Reimers (he/him) ---------- Support SciShow by becoming a patron on Patreon: / scishow ---------- Huge thanks go to the following Patreon supporters for helping us keep SciShow free for everyone forever: Adam Brainard, Alex Hackman, Ash, Benjamin Carleski, Bryan Cloer, charles george, Chris Mackey, Chris Peters, Christoph Schwanke, Christopher R Boucher, DrakoEsper, Eric Jensen, Friso, Garrett Galloway, Harrison Mills, J. Copen, Jaap Westera, Jason A Saslow, Jeffrey Mckishen, Jeremy Mattern, Kenny Wilson, Kevin Bealer, Kevin Knupp, Lyndsay Brown, Matt Curls, Michelle Dove, Piya Shedden, Rizwan Kassim, Sam Lutfi ---------- Looking for SciShow elsewhere on the internet? SciShow Tangents Podcast: https://scishow-tangents.simplecast.com/ TikTok: / scishow Twitter: / scishow Instagram: / thescishow Facebook: / scishow #SciShow #science #education #learning #complexly ---------- Sources: https://www.fda.gov/news-events/press... https://www.gov.uk/government/news/mh... https://www.ema.europa.eu/en/medicine... https://www.statnews.com/2023/12/15/e... https://www.nhlbi.nih.gov/health/sick... https://www.nhlbi.nih.gov/health/sick... https://www.nhlbi.nih.gov/health/sick... https://www.nhlbi.nih.gov/health/sick... https://www.nhlbi.nih.gov/health/sick... https://www.nhlbi.nih.gov/health/sick... https://www.hopkinsmedicine.org/healt... https://www.ncbi.nlm.nih.gov/books/NB.... https://www.nejm.org/doi/10.1056/NEJM... https://www.nejm.org/doi/full/10.1056... https://www.nejm.org/doi/full/10.1056... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.npr.org/sections/health-s... https://www.npr.org/sections/health-s... https://www.npr.org/sections/health-s... https://www.npr.org/sections/health-s... https://www.yalemedicine.org/news/gen... https://www.casgevy.com/sickle-cell-d... https://www.broadinstitute.org/what-b... https://www.broadinstitute.org/what-b... https://www.ncbi.nlm.nih.gov/books/NB... https://bitesizebio.com/41748/a-begin... https://www.casgevy.com/sickle-cell-d... https://www.mybluebirdsupport.com/qua... Images: https://www.gettyimages.com/