ResearchCon 2023 |What’s Bugging You? Managing CF Lung Infections & Addressing Antibiotic Resistance скачать в хорошем качестве

ResearchCon 2023 |What’s Bugging You? Managing CF Lung Infections & Addressing Antibiotic Resistance

Despite amazing advances in cystic fibrosis care, many people with CF find themselves dealing with difficult-to-treat infections. New treatments and strategies are needed, and researchers are working harder than ever to understand how best to detect, diagnose, and treat these organisms. In this session, leading CF researchers and clinicians provide a peek behind the curtain to look at the current landscape of CF lung infections, including innovative approaches to tackle drug-resistant bacteria and the role of clinical trials in advancing these new therapies. In addition to the latest research, presenters discuss the day-to-day management of infections and the importance of proper antibiotic stewardship. Hear personal stories from Nicole Kohr, an adult with CF, highlighting why the science matters — both the progress made and challenges remaining — in this exciting area of research. Originally recorded April 27, 2023. 00:00:00 | What’s Bugging You? Updates on Managing CF Lung Infections and Addressing Antibiotic Resistance 00:03:08 | Nicole shares her CF and infection story 00:11:54 | Poll question: Have you heard of phage therapy, gallium therapy, or the CF Foundation Infection Research Initiative? 00:14:09 | Overview of the Infection Research Initiative 00:18:43 | Current pipeline of anti-infective therapies in development 00:20:19 | What is phage therapy? 00:23:44 | CF Foundation-funded research in phage therapy 00:24:33 | What is gallium citrate? 00:26:18 | Use of gallium as an antimicrobial treatment in CF 00:29:49 | Poll question: Have you ever participated in a CF clinical trial? 00:32:12 | Safety concerns are a principle barrier to participating in clinical trials 00:35:19 | How is participant safety protected in CF clinical trials? 00:40:11 | Nicole shares her experience participating in CF clinical trials 00:44:25 | Poll question: What side effects have you experienced while taking antibiotics? 00:46:51 | What is antibiotic stewardship? 00:49:51 | Steps in putting together an antibiotic treatment plan: who, what, when, where, why, and how 00:59:45 | Nicole shares her experience with antibiotics and side effects 01:03:40 | Conclusions and ways to get involved 01:08:12 | Which bacteria are being targeted by phage therapy? Are there any phage therapy trials for NTM? 01:09:33 | How common is it for new patients to be put on an antibiotic after the first positive culture? 01:10:46 | Does gallium also affect good bacteria? 01:11:59 | What effect would gallium have on someone who is sensitive to metals? 01:12:33 | What advice would you give to a young child who is growing resistant bacteria in their lungs? Would your advice change for an older patient? 01:14:00 | Does the rising number of pregnancies in CF pose any challenge in terms of treatment options?