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When we imagine spaceflight, we often focus on rockets, spacewalks, and distant destinations. But sending humans into space is not just an engineering challenge—it is a biological, medical, and social one. Drawing on personal experience as a physician and astronaut, this talk explores what happens to the human body and mind in space, from bone loss and cardiovascular changes to stress, isolation, and cultural dynamics aboard spacecraft. It examines how space medicine, telemedicine, and human-centered technologies make long-term spaceflight possible—and how these innovations are already transforming healthcare on Earth. Bernard A. Harris, Jr is a physician, former NASA astronaut, and venture capitalist who has spent more than two decades investing in telemedicine and frontier technologies that connect health, humanity, and innovation. A veteran of space shuttle missions and a key member of NASA’s Commercial Space Committee, he helped shape the strategy that ignited today’s boom in private space ventures. Bridging medicine, entrepreneurship, and exploration, Dr. [Name] continues to inspire a new generation to see space not as the final frontier—but as the next great marketplace of ideas, discovery, and human potential. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx