Wide-Angle X-ray Scattering (WAXS) of Structured RNA, Yen-Lin Chen, PhD Defense, AEP, Cornell 2020 скачать в хорошем качестве

Wide-Angle X-ray Scattering (WAXS) of Structured RNA, Yen-Lin Chen, PhD Defense, AEP, Cornell 2020

This was the zoom recoding for my PhD defense for the School of Applied and Engineering Physics at Cornell University on 11/20/2020 2-3pm ET. I talked about Wide-Angle X-ray Scattering (WAXS) on structured RNAs, touching atomic structural modeling of the experimental data, machine learning methods, molecular dynamics simulations and finally, a novel algorithm that reveals 3D electron density distributions of RNA systems using just the experimental WAXS profile. My committee members: Prof. Lois Pollack (Applied and Engineering Physics) Prof. Sumanta Basu (Statistical Sciences) Prof. Warren Zipfel (Biomedical Engineering) My Ph.D Thesis can be found on ProQuest/Cornell Library: Bridging Theories and Experiments: Modeling Solution X-Ray Scattering of Small RNA Molecules https://search.proquest.com/openview/... (Updated) My additional publications after my defense as of 4/25/2021: 1. The structural plasticity of nucleic acid duplexes revealed by WAXS and MD, Science Advances, 2021 https://doi.org/10.1126/sciadv.abf6106 2. Structural analyses of an RNA stability element interacting with poly(A), Proc. Natl. Acad. Sci. U.S.A. 2021 https://doi.org/10.1073/pnas.2026656118 (Updated) arXiv Preprint as of 4/25/2021 1. In Vitro Electron Density Refinement from Solution X-ray Scattering in the Wide-Angle Regime, arXiv Preprint 2020 https://arxiv.org/abs/2012.13370 Github demo: https://github.com/jipq6175/FM My published work as of 11/20/2020: 1. Elucidating the Role of Microprocessor Protein DGCR8 in Bending RNA Structures, Biophys. J., 2020 https://doi.org/10.1016/j.bpj.2020.10... 2. Machine learning deciphers structural features of RNA duplexes measured with solution X-ray scattering, IUCrJ, 2020 https://doi.org/10.1107/S205225252000... Github: https://github.com/jipq6175/IUCrJ_MLWAXS 3. Salt Dependence of A-Form RNA Duplexes: Structures and Implications, J. Phys. Chem. B 2019 https://doi.org/10.1021/acs.jpcb.9b07502 4. Conformations of an RNA Helix-Junction-Helix Construct Revealed by SAXS Refinement of MD Simulations, Biophys. J. 2019 https://doi.org/10.1016/j.bpj.2018.11... 5. How the Conformations of an Internal Junction Contribute to Fold an RNA Domain, J. Phys. Chem. B 2018 https://doi.org/10.1021/acs.jpcb.8b07262 LinkedIn:   / ychen2253   Email: [email protected]