Structural Heterogeneity in Focus: Preparing for Cryo-EM Success скачать в хорошем качестве

Structural Heterogeneity in Focus: Preparing for Cryo-EM Success

Want to understand how cryo-EM can reveal epitope-paratope interactions—even in samples with significant conformational dynamics? Dr. Kenny Kang, Senior Scientist at NanoImaging Services, demonstrates how cryo-EM can visualize discrete states within conformationally flexible samples, using the SARS-CoV-2 spike protein as a case study. This work shows how states that typically produce blurred or unresolved maps can instead be captured and distinguished. You’ll see how cryo-EM enables direct observation of receptor-binding domain motion and overcomes limitations inherent to static structural techniques.