SANS 2019: Nathan Spreng, "Loneliness and meaning in life are reflected in the intrinsic network..." скачать в хорошем качестве

SANS 2019: Nathan Spreng, "Loneliness and meaning in life are reflected in the intrinsic network..."

Social Affective Neuroscience Conference 2019 Symposium 1: Social Neuroscience Meets Network Neuroscience Nathan Spreng: "Loneliness and meaning in life are reflected in the intrinsic network architecture of the brain" Social relationships imbue life with meaning, whereas loneliness diminishes the sense of meaning in life. Yet the extent of interdependence between these psychological constructs remains poorly understood. Loneliness and meaning are associated with different patterns of functional connectivity; however, no studies have investigated this directly. We took a multivariate network approach to examine resting-state fMRI functional connectivity’s association with loneliness and meaning in a large cohort of adults (N=942). Loneliness and meaning in life were negatively correlated with one another. Functional brain regions were individually parcellated. Whole-brain measures of functional connectivity were then related to meaning and loneliness and a significant and reliable pattern was observed. Greater loneliness was associated with dense, and less modular, connections between default, frontoparietal and externally-directed attention and perceptual networks. A greater sense of life meaning was associated with increased, and more modular, connectivity between default and limbic networks. Low loneliness was associated with more modular brain connectivity, and lower life meaning was associated with higher between-network connectivity. These findings advance our understanding of loneliness and life meaning as distinct, yet interdependent, features of sociality. The results highlight a potential role of the default network as a central hub, providing a putative neural mechanism for shifting between feelings of isolation and purpose.