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Vesiculobullous dermatoses are a group of skin disorders characterized by the formation of vesicles (small fluid-filled blisters) and bullae (larger blisters). These conditions can result from various causes, including autoimmune diseases, infections, or drug reactions. Here's a brief overview: Common Types: Pemphigus Vulgaris: An autoimmune condition causing flaccid blisters on the skin and mucous membranes. Bullous Pemphigoid: Another autoimmune disorder, but with tense, large blisters, often in older adults. Dermatitis Herpetiformis: Associated with gluten sensitivity, presenting as intensely itchy blisters. Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN): Severe drug reactions leading to widespread blistering and skin detachment. Diagnosis: Clinical examination of the blisters' appearance and distribution. Skin biopsy with histopathology and direct immunofluorescence to identify autoimmune causes. Laboratory tests, such as blood tests or cultures, to rule out infections. Treatment: Depends on the underlying cause. Autoimmune conditions often require corticosteroids or immunosuppressants. Supportive care, such as wound management and infection prevention, is crucial for severe cases like SJS/TEN. #dermatoses