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This third installment in the World Trade Center (WTC) Health Program’s Clinical Best Practices seminar series summarized obstructive sleep apnea (OSA) research findings among persons with 9/11 exposures and discussed diagnostic and treatment best practices for OSA. This webinar: -Discussed early studies of 9/11-exposed persons that showed an excess of aerodigestive diseases including rhinosinusitis and gastroesophageal reflux, which might increase the risk for OSA. -Discussed studies of World Trade Center (WTC) responders that report an excess of OSA among those who developed new onset or worsening chronic rhinosinusitis. -Summarized the diagnostic and treatment best practices from OSA guidelines produced by the American Academy of Sleep Medicine and the Department of Veterans Affairs/Department of Defense. Webinars in the Best Practices for Clinical Care series are recorded and generally available within 4 weeks after the live session. You can view past webinar recordings at www.cdc.gov/wtc/clinicalcarewebinars.html DISCLAIMER: The views expressed in these Best Practices webinars do not necessarily reflect the official policies or views of the Department of Health and Human Services, the Centers for Disease Control and Prevention (CDC), or NIOSH; nor does the mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.