Confocal Imaging: Abnormal mitosis in cancer cells | Protocol Preview скачать в хорошем качестве

Confocal Imaging: Abnormal mitosis in cancer cells | Protocol Preview

Watch the Full Video at https://www.jove.com/v/50568/cell-dea.... Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells - a 2 minute Preview of the Experimental Protocol Asher Castiel, Leonid Visochek, Leonid Mittelman, Yael Zilberstein, Francoise Dantzer, Shai Izraeli, Malka Cohen-Armon Sheba Medical Center, Cancer Research Center; Tel-Aviv University, The Neufeld Cardiac Research Institute; Tel-Aviv University, Department of Physiology and Pharmacology; Tel-Aviv University, Imaging Unit, Sackler Faculty of Medicine; Ecole Superieure de Biotechnologie Strasbourg, Biotechnology and Cell Signaling; Tel-Aviv University, Department of Human Molecular Genetics and Biochemistry; The cytotoxic activity of the phenanthridine PJ-34 in cancer cells undergoing mitosis was documented in real time by live confocal imaging. PJ-34 eradicated human breast cancer MDA-MB-231 cells harboring extra-centrosomes in mitosis. Unlike normal bi-focal mitosis, the extra-centrosomes were not clustered in the two spindle poles in the presence of PJ-34. Visit https://www.jove.com?utm_source=youtu... to explore our entire library of 14,000+ videos of laboratory methods and science concepts. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching. Subscribe to our channel:    / jovejournalofvisualizedexperiments