Galenics: Making drugs actually work! | Karsten Mäder | TEDxUniHalle скачать в хорошем качестве

Galenics: Making drugs actually work! | Karsten Mäder | TEDxUniHalle

How does a drug molecule know its desired location to act? Why do we still need injections? There are much more questions to ask to ensure a safe and efficient medical treatment. Common problems of drug therapy include (1) poor absorption, (2) rapid excretion and metabolism, (3) non-specific distribution and (4) high toxicity. As a result, patients suffer from inefficient drug treatment, side effects and a high number of injections. Pharmaceutical technology (Galenics) offers solutions to the dilemma. The location and release kinetics of the drug is controlled by an appropriate drug delivery system (DDS). For example, biodegradable polymers or lipids can be used to deliver drugs over weeks to several months. Such systems are clinically used for the treatment of prostate and breast cancer. However, many of them show undesirable release kinetics and therefore, improvements are needed. Biodegradable DDS are also urgently needed to improve drug therapy to the eyes and ears. Nano-DDS can be designed to reach tumour tissue more specific. In addition, a specific release of the drug can be achieved by stimulus sensitive delivery systems. Such strategies can improve the efficacy and safety of drug treatment. However, unexpected findings (e.g. the undesired accumulation of some Nano-DDS in the ovaries and adrenals) indicates that further research is needed to get the drug exclusively to its desired location. Karsten Mäder obtained his PhD in Pharmacy at the Humboldt-University Berlin. After his postdoc at Dartmouth Medical School (NH, USA) he completed his Habilitation in Berlin. Academic (Philipps-University Marburg, FU Berlin) and industrial (Roche, Basel) research positions followed. Since 2003 Karsten is Full Professor of Pharmaceutics at the Martin Luther University Halle-Wittenberg. He published around 180 papers, several book chapters and patents. Karsten Mäder is member of the editorial board of several journals, including Journal of Controlled Release. He received several awards, including the APV Research Award for Outstanding Achievements in Pharmaceutical Sciences. His main working areas are Drug Delivery Systems for improved cancer therapy and biodegradable depot systems. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx