HIF Repress Pathways An Insight into Cellular Oxygen Homeostasis скачать в хорошем качестве

HIF Repress Pathways An Insight into Cellular Oxygen Homeostasis

https://www.assaygenie.com/epigenetic... Main Themes: Hypoxia-inducible factors (HIFs) are crucial regulators of cellular response to low oxygen (hypoxia). While primarily known for activating genes, their role in repressing pathways is equally important. HIF-mediated repression is vital for cellular adaptation to hypoxia. This includes metabolic shifts, control of cell proliferation, and potential implications for tumor progression. Key Ideas and Facts: HIFs employ various mechanisms for gene repression:Indirect transcriptional repression: Inducing other transcription factors or repressors that inhibit target genes. Competition for co-factors: Sequestering co-factors needed by other transcription factors, indirectly downregulating their target genes. Epigenetic modifications: Interacting with histone-modifying enzymes to create a closed chromatin structure, inhibiting gene expression. Biological implications of HIF repress pathways:Metabolic shift: HIFs repress genes involved in aerobic metabolism, facilitating the switch to anaerobic processes under hypoxia. Cell proliferation and survival: Repressing pathways crucial for cell division, preventing unnecessary energy expenditure and supporting cell survival in resource-limited hypoxic conditions. Tumor progression: Repression of apoptosis-related genes may contribute to tumor survival and growth. Important Quotes: "HIFs function primarily as transcriptional activators. However, they can indirectly repress gene expression by various mechanisms." "This repression is significant in the context of hypoxia, where resources are limited, and it is not favorable for cells to proliferate." "In the context of cancer, HIF-mediated repression pathways can have profound implications...a key area of research in understanding cancer biology and developing potential therapeutic strategies."