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Oriole Resources PLC (AIM:ORR) said it made progress on “all fronts” in 2024, as the West Africa-focused exploration group stepped up drilling in Cameroon, signed two earn-in deals, and pushed forward with a key licence application. The focus is now on what happens next at Mbe, its flagship exploration project within the Central Licence Package. Ananda Pharma Plc (AQSE:ANA) has received ethics approval in Australia to begin its first human trial of chronic pain treatment MRX1. Dosing starts later this year, with early trial results expected in early 2026. Empyrean Energy PLC (AIM:EME) will start testing a potential oil zone at the Wilson River-1 well later this month. It's also reviewing other promising areas that could add upside. Zinnwald Lithium PLC (LSE:ZNWD, OTC:ZNWLF) got a major boost after its German lithium project was named a “project of outstanding importance” by Saxony’s government. The mine could deliver over 35,000 tonnes of lithium hydroxide a year and now has state-level backing. Electric Guitar PLC (AIM:ELEG) is back on AIM with new leadership and over 1.2 billion shares in play. It has until June to close a reverse takeover or become an investing company—or face suspension again.