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On February 19, 2026, the American College of Cardiology (ACC) and American Heart Association (AHA) released a clinical practice guideline for acute pulmonary embolism (PE) treatment, the first of its kind from these institutions. Prominent among this guideline is a new clinical classification scheme, dividing patients into 5 main categories A through E, equivalent to low to high risk of adverse outcomes. Category A includes patients exhibiting incidental and asymptomatic embolism, with no subgroups. Category B includes symptomatic patients with a low clinical severity score and is divided into B1, which includes subsegmental presentations, and B2, which includes non-subsegmental presentations. Category C includes patients with an elevated clinical severity score and is comprised of three subgroups. C1 includes those with normal RV and normal biomarkers; C2 includes abnormal RV or ≥1 abnormal biomarker; C3 includes patients with both abnormal RV and ≥1 abnormal biomarker. Category D includes patients with incipient cardiopulmonary failure: D1 includes patients with transient hypotension, while D2 includes those with normotensive shock. Finally, Category E is cardiopulmonary failure, with E1 including recurrent or persistent hypotension with cardiogenic shock and E2 including refractory cardiogenic shock or cardiac arrest. Now, in an interview with HCPLive, Mark Creager, director emeritus of the heart and vascular center at Dartmouth University and chair of the committee, discussed the high points of these guidelines and the research that still needs to be done. “This is a new clinical categorization of acute pulmonary embolism, and we’re using this to help guide clinicians who are managing patients with acute pulmonary embolism in how they can manage these patients most effectively and most safely,” Creager told HCPLive. Key Timestamps 00:00:01 Intro 00:00:09 Guideline overview 00:06:58 Anticoagulation in complex situations 00:07:44 Interdisciplinary teams 00:10:06 Evidence gaps and future research 00:13:24 Next steps #cardiology #pulmonaryembolism