New Drugs Cut Lp(a) Over 90%...Will They Prevent Heart Attacks? скачать в хорошем качестве

New Drugs Cut Lp(a) Over 90%...Will They Prevent Heart Attacks?

In this video, we explore the exciting pipeline of drugs targeting lipoprotein a and its implications for cardiovascular disease prevention. We'll examine how these cholesterol drugs are designed to work, including those utilizing sirna technology, and discuss the reasons for both enthusiasm and caution regarding this medical breakthrough. This discussion aims to clarify the current landscape of new treatments and what questions still need answers. Here’s what I cover: The strategy for lowering Lp(a): stop production vs block assembly (it’s basically all in the liver) The late-stage / headline agents and trials: Pelacarsen (ASO) — Lp(a)HORIZON Olpasiran (siRNA) — OCEAN(a) Lepodisiran (siRNA)— ACCLAIM-Lp(a) (enrolling) Zerlasiran / SLN360 (siRNA) — development in flux Muvalaplin (oral assembly inhibitor)— KRAKEN (phase 2) Why I’m genuinely hopeful: plasmapheresis is a “proof-of-concept” that lowering Lp(a) might reduce events (with important confounders) Why I’m still skeptical until outcomes data lands: the graveyard of “should-have-worked” drugs (CETP inhibitors, canakinumab—great biomarker/endpoint signals, messy real-world tradeoffs) My 5-question framework for evaluating any new cardiometabolic drug the moment it hits the market: 1. What problem does it actually solve—and how big is the benefit? 2. How strong/unbiased is the evidence (and do we have outcomes)? 3. Who is the right target (and who wasn’t in the trial)? 4. What are the tradeoffs (side effects, cost, duration, unknowns)? 5. Would I take it? Would I give it to my mom—under what conditions? References: Lp(a) HORIZON Phase 2 - DOI: 10.1056/NEJMoa1905239 OCEAN(a) Phase 2: DOI: 10.1056/NEJMoa2211023 ALPACA Phase 2: DOI: 10.1056/NEJMoa2415818 Zerlasiran Phase 2: doi:10.1001/jama.2024.21957 KRAKEN Phase 2: doi:10.1001/jama.2024.24017 ___________________________ Sign up for more information on my own practice here: https://corsighthealth.com/ Other tools for optimal health (note these are affiliate links): Home BP Cuff: https://amzn.to/49Cq7rh Sonicare Toothbrush: https://amzn.to/3KllfMS WaterPik: https://amzn.to/4894Xi8 Apple Watch with sleep & HR monitoring: https://amzn.to/3XaUn5d Oura Ring with sleep, cycle, and recovery monitoring: https://amzn.to/4riyhLS Intake Breathing Nasal Support: https://amzn.to/48dfQQ1 Personal Blender: https://amzn.to/4pyNGGl True Nutrition Protein: https://oken.do/q2xzqeqw Glass Meal Prep Containers: https://amzn.to/4ocEPJ2 Sleep Mask: https://amzn.to/48fSJV5 Air Purifier: https://amzn.to/4puzTQZ Buy me a coffee: https://buymeacoffee.com/lilyjohnstonmd ___________________________ 🧬 About Dr. Lily Johnston Dr. Johnston is a double board-certified vascular and general surgeon in San Diego, specializing in metabolic and cardiovascular prevention. She’s the founder of CorSight Health and a passionate advocate for reimagining how medicine approaches chronic disease. #MetabolicHealth #CardiovascularPrevention #HeartHealth #Longevity #InsulinResistance #DrLilyJohnston #DrLily #WomenInMedicine #Surgeon #VascularSurgeon #PreventiveMedicine #PADPrevention #HeartAttackRisks #HealthPortfolio #California #SanDiego #Arizona #Virginia #minnesota