Breakthroughs in urothelial cancer treatment at ESMO 2023 скачать в хорошем качестве

Breakthroughs in urothelial cancer treatment at ESMO 2023

Joaquim Bellmunt, MD, PhD, Harvard Medical School, Boston, MA, highlights key findings from ESMO 2023. The Phase III EV-302 (NCT04223856) study assessed enfortumab vedotin and pembrolizumab (EV+P) versus standard chemotherapy in untreated advanced/metastatic urothelial cancer. EV+P significantly improved progression-free survival (PFS) and overall survival (OS), reducing progression and death risks by 55% and 53%, respectively, making it a new standard of care. In the Phase III CheckMate 901 (NCT03036098) trial, nivolumab (NIVO) with gemcitabine-cisplatin (GC) outperformed GC alone in first-line unresectable/metastatic urothelial carcinoma, improving OS and PFS. This marks the first concurrent checkpoint inhibitor and chemo combination enhancing OS in this setting. Dr. Bellmunt also mentions a double antibody drug conjugate (DAD) Phase I trial (NCT04724018) evaluating the combination of EV and sacituzumab govitecan (SG) in metastatic urothelial carcinoma. Despite 70% of patients experiencing grade 3 or higher adverse events, the objective response rate was 71%. Further studies, including triplet therapy with immunotherapy, are being explored for treatment-refractory urothelial carcinoma, suggesting promising directions for bladder cancer treatment. This interview took place at the European Society for Medical Oncology (ESMO) 2023 Congress in Madrid, Spain. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.