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This week we are joined by Dr. Daniel Sun, Director of the Division of Neurotology and Associate Professor of Otolaryngology at the University of Cincinnati College of Medicine, to discuss his pioneering research in hearing loss treatment. Addressing the challenges of delivering large molecule medications to the inner ear, Dr. Sun introduces a novel approach using magnetic nanoparticles. These particles, guided by magnetic fields, could provide a more effective way to deliver treatments directly into the cochlea, offering new possibilities for managing sensorineural hearing loss. Dr. Sun also explores the role of advanced MRI techniques in understanding how the brain adapts to hearing loss. This research aims to develop predictive tools to better assess which patients might benefit from cochlear implants, even after long periods of deafness. Additionally, he shares insights into new software under development that could improve cochlear implant performance, potentially enhancing outcomes for many patients. **Learn more Dr. Sun and his research at the University of Cincinnati here: https://researchdirectory.uc.edu/p/sundl Be sure to subscribe to our YouTube channel for the latest episodes each week, and follow This Week in Hearing on LinkedIn and X (formerly Twitter): / this-week-in-hearing / weekinhearing Audio podcast can be found on all major platforms, including Apple & Spotify: https://podcasters.spotify.com/pod/sh... TIMESTAMPS 00:00 Intro and background 01:42 Challenges of getting medication to inner ear 03:18 Current drug delivery methods to inner ear 05:39 Benefits of using magnetic nanoparticles 09:58 Nanoparticles - Size matters 13:10 Development timeline 17:35 Advanced MRI to examine brain changes after hearing loss 24:02 Smartphone software to improve cochlear implant performance