Nasal Decongestant ll Pharmacology of Alpha Adrenergic Decongestant ll With Notes скачать в хорошем качестве

Nasal Decongestant ll Pharmacology of Alpha Adrenergic Decongestant ll With Notes

Nasal Decongestant ll Pharmacology of Alpha Adrenergic Decongestant ll With Notes Decongestants produce vasoconstriction within the nasal mucosa through α-adrenergic receptor activation and therefore are effective in relieving the symptoms of nasal obstruction. However, these agents have no effect on other symptoms such as rhinorrhea, pruritus or sneezing and may be most effective when used in combination with other agents, such as antihistamines. A number of decongestants are available for oral use, but the most commonly used decongestant is pseudoephedrine. The most common side-effects of oral decongestants are central nervous system (nervousness, insomnia, irritability, headache) and cardiovascular (palpitations, tachycardia) effects. In addition, these drugs may elevate blood pressure, raise intraocular pressure and aggravate urinary obstruction. Topical intranasal decongestants are sometimes used by patients with allergic rhinitis. However, when these agents are used for longer than 3 to 5 days, many patients experience rebound congestion after withdrawal of the drug. If patients continue to use these medications over several months, a form of rhinitis, rhinitis medicamentosa, will develop, which can be difficult to treat effectively. #nasaldecongestant #alphaadrenergicdecongestant #alphaagonist