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In 1997 there were 432 new patents for herbicides, by 2009 there were only 65. The development of broad spectrum glyphosate and “Roundup Ready crops” was a game changer that worked so well people basically stopped looking for new herbicides. That is until the weeds started fighting back. Chemical & Engineering News article on the search for new modes of action https://cen.acs.org/environment/pesti... Introduction to the Shikimate Pathway • Introduction to the Shikimate Pathway You might also like other Reactions videos: How Quinine Fights Malaria, and How That Caused* World War One • How Quinine Fights Malaria, and How That C... That Fresh Cut Grass Scent is Really a Signal of Distress • That Fresh Cut Grass Scent is Really a Sig... How Can Fertilizer Explode? • How Can Fertilizer Explode? How Do Hydrangeas Change Colors? • How Do Hydrangeas Change Colors? The Chemistry of Poison Ivy • The Chemistry of Poison Ivy Credits: Executive Producer: Matthew Radcliff Producers: Elaine Seward Andrew Sobey Darren Weaver Host: Alex Dainis Scientific Consultants: Mark Loux, PhD Patrick J. Tranel, PhD Todd Gaines, PhD Mithila Jugulam, Ph.D. Leila Duman, PhD Brianne Raccor, PhD Executive in Charge for PBS: Maribel Lopez Director of Programming for PBS: Gabrielle Ewing Assistant Director of Programming for PBS: John Campbell Reactions is a production of the American Chemical Society. © 2022 American Chemical Society. All rights reserved. Additional Sources: Molecular basis for the herbicide resistance of Roundup Ready crops https://www.ncbi.nlm.nih.gov/pmc/arti... THE SHIKIMATE PATHWAY https://www.annualreviews.org/doi/10.... Why have no new herbicide modes of action appeared in recent years? https://onlinelibrary.wiley.com/doi/1... The Pitfalls of Relating Weeds, Herbicide Use, and Crop Yield: Don't Fall Into the Trap! A Critical Review https://www.frontiersin.org/articles/... The cost of herbicide resistance https://crops.extension.iastate.edu/b... Development and Characterization of a CP4 EPSPS-Based, Glyphosate-Tolerant Corn Event https://web.archive.org/web/200903190... Tyrosine Biosynthesis, Metabolism, and Catabolism in Plants https://bit.ly/3CsMiiS Biosynthesis and Metabolic Fate of Phenylalanine in Conifers https://www.ncbi.nlm.nih.gov/pmc/arti... Auxin driven indoleamine biosynthesis and the role of tryptophan as an inductive signal in Hypericum perforatum (L.) https://www.ncbi.nlm.nih.gov/pmc/arti... Finding of No Significant Impact Animal and Plant Health Inspection Service Petition for Non-regulated Status for Soybean Line MON 89788 (APHIS 06-178-01p) https://www.aphis.usda.gov/brs/aphisd... Glyphosate resistance: state of knowledge https://onlinelibrary.wiley.com/doi/p...