Ubiquitin-Proteasome System | Targeted Protein Degradation скачать в хорошем качестве

Ubiquitin-Proteasome System | Targeted Protein Degradation

The *ubiquitin-proteasome system (UPS)* is the cell’s natural mechanism for protein turnover and is at the center of new research into **targeted protein degradation**. In this video, we provide a clear introduction to the UPS pathway, its components, and how scientists are leveraging this system to study difficult-to-target proteins and advance therapeutic discovery. You’ll learn: The roles of E1, E2, and E3 ligases in the ubiquitination cascade. How ubiquitin tags proteins for degradation and directs them to the proteasome. The mechanism of proteolysis targeting chimeras (PROTACs). How targeted protein degradation provides new strategies to address undruggable proteins. Examples of using the UPS to study targets like BRD4 and CDK9. This video highlights the science behind UPS and its application in disease biology and drug discovery. Learn more: https://www.thermofisher.com/us/en/ho... Chapters: 00:00 – Why Study Protein Degradation? 00:40 – Introduction to the Ubiquitin-Proteasome System 01:30 – E1, E2, and E3 Ligases Explained 02:15 – Targeted Protein Degradation with PROTACs 03:20 – Applications in Drug Discovery and Research 04:10 – Thermo Fisher Tools for Protein Biology Related Videos: Principles of PCR →    • PCR Denaturation, Annealing & Extension Ex...   Genome Editing with Engineered Nucleases →    • Genome Engineering Training: Precise Gene ...   - Transfection Overview →    • How to Start with the Attune NxT Flow Cyto...