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Think a fistula will heal on its own? In Crohn’s disease, fistulas—abnormal tunnels between the bowel and other organs or the skin—almost always need expert intervention. Treatment usually combines medicine and surgery for the best chance at healing. Antibiotics like metronidazole or ciprofloxacin can help with infection and inflammation, but rarely close the fistula alone. Biologics, especially anti-TNF drugs like infliximab, are the gold standard for promoting closure, often used alongside surgery. Newer biologics (adalimumab, ustekinumab, vedolizumab, risankizumab) and even stem cell therapies are emerging options for tough cases. Surgical options depend on the fistula’s complexity and location: seton insertion keeps the tract draining to prevent abscesses, fistulotomy opens the tract for healing (best for simple fistulas), and procedures like plugs, glue, LIFT, or endorectal advancement flap are used for more complex cases—each with its own benefits and risks. Most fistulas need some form of intervention—medical, surgical, or both—to prevent ongoing infection and complications. Here’s the truth: with the right combination of advanced medicine and surgery, even stubborn fistulas can be managed—so you can focus on healing, not just coping. Follow @thegrumblinggut if you found this helpful! Make sure you like, share, comment, and save this post if you found it helpful. #thegrumblinggut #inflammatoryboweldisease #crohnsdisease #ulcerativecolitis #microscopiccolitis #ibd #crohns #colitis Instagram/Facebook/YouTube/TikTok: @thegrumblinggut Disclaimer: Information provided here is for educational purposes only and not intended to replace the advice or the services of trained healthcare professionals or be a substitute for medical advice, diagnosis, or treatment. #fistula #perianalfistula #fistulatreatment #seton #biologics #stemcelltherapy #crohnscomplications #ibdsurgery #guthealth