Factors influencing MPN progression скачать в хорошем качестве

Factors influencing MPN progression

Andrew Kuykendall, MD, H. Lee Moffitt Cancer Center, Tampa, FL, outlines the factors that may drive myeloproliferative neoplasm (MPN) progression such as inflammation and lifestyle choices as well as genetic susceptibility. Dr Kuykendall additionally highlights findings from a recent study which looks at the molecular abnormalities in the chronic phase and discusses the contributory role played by splicing mutations in increasing the risk of progression from the chronic phase to myelofibrosis. Dr Kuykendall also comments on factors influencing leukemic transformation, such as p53 mutations, MDM4 or MDM2 overexpression, IDH2 mutations and SRFS2 mutations. This interview took place at the Texas MPN Workshop: Second Annual Workshop and Meeting in 2021.