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Management of PDA in the preterm population continues to be a hot topic with no clear resolution of the debate. Majority of the babies at or above 28 weeks would not need any specific treatment for the duct, with less than 10% of such babies needing pharmacologic treatment. In the babies under 28 weeks, a higher percentage of babies could undergo treatment-the early targeted echocardiography could be the way forward in picking which of these babies are likely to benefit. Paracetamol (15 mg/kg/dose QID) might be preferred in the first week due to better safety profile, and oral form could be more effective if baby could tolerate the oral route. Ibuprofen (traditional dose at 10-5-5 mg at 24 hour interval) is more likely to be used effectively after the first week. In more mature babies, a higher dose of Ibuprofen (20-10-10 mg at 24 hour interval) could be considered as it might be more effective. #PDA #nicu #patentductus