Probing cell surface target internalization in cancer and immunology скачать в хорошем качестве

Probing cell surface target internalization in cancer and immunology

Presented By: Dan Beacham, Ph.D. Speaker Biography: As a Senior Staff Scientist at Thermo Fisher Scientific, Dan develops cell-based imaging, high throughput screening and biochemical tools for drug discovery and basic sciences research. Dan holds an undergraduate degree in Chemistry from Willamette University and a Ph.D. in Neurobiology from Oregon Health and Sciences University. He came to the Eugene campus of Thermo Fisher Scientific in 2006 following postdoctoral research at University College London and the University of Washington in Seattle, where he studied molecular mechanisms of ion channel and GPCR control of excitability. Dan's work at Thermo Fisher Scientific spans the development of toolboxes to interrogate excitability, cell surface target internalization, antibody-drug conjugate biology and metabolic states in disease. Webinar: Probing cell surface target internalization in cancer and immunology Webinar Abstract: Fluorescence imaging offers robust, multi-parametric and scalable analysis of cell-level activity in heterogenous populations with excellent spatial and temporal resolution. This seminar will provide an overview of practical considerations for assay development in cancer and immunology research, covering platform and newly developed probes for microscopic studies of cell surface target internalization, trafficking, phagocytosis and endocytic mechanism of action. Concomitant or serial readouts for apoptosis, cell health and stress will be reviewed as companion assays in the context of Antibody-Drug Conjugate (ADC) labeling, delivery and lysosomal degradation. Learning Objectives Best practices in live-cell imaging assay development Leveraging endosomal pH to quantify internalization and trafficking Use of pathway and endpoint indicators for cell health and stress Labroots on Social: Facebook:   / labrootsinc   Twitter:   / labroots   LinkedIn:   / labroots   Instagram:   / labrootsinc   Pinterest:   / labroots   SnapChat: labroots_inc