|Drugs Metabolism| Pharmacology скачать в хорошем качестве

|Drugs Metabolism| Pharmacology

📚 Drug Metabolism | Phase I & Phase II Reactions | Cytochrome P450 Explained In this lecture, we discuss the metabolism of drugs in the body and how the body converts lipophilic (fat-soluble) drugs into hydrophilic (water-soluble) compounds so they can be easily excreted. The video explains the two major phases of drug metabolism: 🔹 Phase I Reactions (Functionalization Reactions) • Introduction of functional groups such as –OH and –NH₂ • Oxidation, reduction, and hydrolysis reactions • Role of the Cytochrome P450 (CYP450) enzyme system • Metabolism of drugs, carcinogens, and environmental chemicals 🔹 Phase II Reactions (Conjugation Reactions) • Conjugation with endogenous substances such as glucuronic acid, sulfuric acid, acetic acid, and amino acids • Formation of highly polar and water-soluble metabolites • Glucuronidation as the most common conjugation reaction • Final excretion through kidneys or bile This lecture is very helpful for Pharmacy, Medical, and Pharmacology students who want to understand the mechanism of drug metabolism in the liver. 👍 If you find this lecture helpful, like the video, share it with classmates, and subscribe to the channel for more pharmacology lectures. #DrugMetabolism #Phase1Reaction #Phase2Reaction #CytochromeP450 #Pharmacology #PharmacyStudents #MedicalStudents #DrugBiotransformation #PharmacologyLecture