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Drs Chris and Xand van Tulleken explore the use of psychedelics to help treat clinical depression in patients where other treatments have failed. Chris and Xand meet Dr James Rucker, a consultant psychiatrist at King's College London who is leading the European arm of a global trial of a psychedelic called psilocybin in a study designed to treat people with severe depression for whom other pharmacological treatments have failed. The use of psychedelics in both traditional medicinal and spiritual ceremonies dates back thousands of years and examples include peyote and ayahuasca from Central and South America, Iboga root from Central Africa and LSD, which is synthesised from a fungus found throughout Europe. As the number of clinical trials involving psychedelics increases, scientists are cautiously optimistic that they may be able to help with a range of conditions from eating disorders and anxiety to depression and addiction. 0:00 Coming up 0:36 What are psychedelics and how do they work? 1:34 Examples of psychedelics 2:17 Psilocybin trial for depression - How does it work? 3:18 Patient experience during psychedelic therapy 5:06 Why active participation is necessary 6:23 Inclusion criteria in psilocybin trial 6:41 Psilocybin trial results 10:43 Psychedelic therapy for anxiety, OCD, anorexia, PTSD, addiction 11:03 Psychosis and schizophrenia - Why psychedelic treatments are not feasible 11:26 Will there be a psychedelics revolution? 11:53 How does Dr James’ expert knowledge affect his life? Welcome to What’s Up Docs?, the podcast where doctors and identical twins Chris and Xand van Tulleken untangle the confusion around every aspect of our health and wellbeing. ------------------------------------------------------------------------------------------------------------------------- Subscribe and 🔔 to BBC Sounds YouTube: https://www.youtube.com/c/bbcsounds?s... Listen to the full episode here: Find more episodes of What's Up Docs? here: www.bbc.co.uk/sounds/brand/m00298p7 Watch more What's Up Docs? videos: • What's Up Docs? Fresh on BBC Sounds playlist: • Fresh on BBC Sounds Fresh on BBC Sounds playlist: • Fresh on BBC Sounds ------------------------------------------------------------------------------------------------------------------------- #ChrisVanTulleken #XandVanTulleken #WhatsUpDocs We are BBC Sounds. The home of binge-worthy podcasts, music curated by music lovers and live radio.