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Aldosterone: Regulation of Secretion and Effects

This video provides a foundational explanation about where aldosterone comes from, the stimuli that cause aldosterone secretion, and the effects of aldosterone. 0:12 Adrenal cortex and adrenal medulla 0:27 Diagram showing the microscopic appearance of the adrenal cortex: zona glomerulosa, zona fasciculata, and the zona reticularis 1:16 Zona glomerulosa secretes a family of steroid hormones called mineralocorticoids 1:32 Explanation of the typical extracellular fluid (ECF) composition regarding the relative concentrations of sodium and potassium ions 2:19 Aldosterone secretion is stimulated in 3 ways 2:27 Humoral regulation of aldosterone secretion (changing concentrations of potassium and sodium in the ECF) 2:54 Primary effects of aldosterone 3:20 Secondary effects of aldosterone 3:40 Hormonal regulation of aldosterone release: ACTH (circadian rhythm, stress) 4:41 Angiotensin II stimulates aldosterone release 4:49 Explanation about why blood pressure is vital to kidney function/filtration 5:56 Drop in blood pressure stimulates renin secretion from the kidney 6:18 Source of angiotensinogen 6:29 Angiotensin I 6:39 Angiotensin II 6:47 Angiotensin converting enzyme (ACE) 6:55 Effects of angiotensin II on the zona glomerulosa 7:05 Primary and secondary effects of aldosterone 7:27 Summary of the 3 mechanisms that lead to the secretion of aldosterone