Webinar: Two mutations in RNA splicing factors from the same cell confirmed with single-cell DNA-Seq скачать в хорошем качестве

Webinar: Two mutations in RNA splicing factors from the same cell confirmed with single-cell DNA-Seq

See our latest video: "What If "    • What If   -~- Challenging the dogma that single nucleotide variants (SNVs) in RNA splicing factors do not occur in the same cell due to their synthetic lethal interactions and/or convergent effects, Dr. Justin Taylor from the Abdel-Wahab lab at Memorial Sloan Kettering Cancer Center shows that indeed they can. Using Mission Bio's single-cell sequencing platform, they sequenced close to 100,000 single cells and found instances in which mutations in splicing factors co-occurred within the same cells. Dr. Taylor shares his and his co-authors' recent publication in the journal Blood, which looks at rare patients with myeloid malignancies with mutations in two RNA splicing genes. Mission Bio delivers targeted solutions for high-impact applications with the Tapestri Platform. The Tapestri Platform is the industry’s first and only single-cell multi-omics platform, enabling genotype and phenotype from the same cell and precise detection of heterogeneity in disease progression and treatment response. Application areas include oncology blood cancers, solid tumors, and genome editing validation to name a few. Learn more about Mission Bio: https://missionbio.com/ LinkedIn:   / mission-bio   Twitter:   / missionbio   Facebook:   / missionbio   Subscribe to our emails and updates: https://go.missionbio.com/l/552252/20...