Скачать с ютуб Erik Jorgensen (U. Utah / HHMI) 1: Synaptic transmission в хорошем качестве

Erik Jorgensen (U. Utah / HHMI) 1: Synaptic transmission

https://www.ibiology.org/neuroscience... Part 1: Synaptic Transmission: Jorgensen describes the historic experiments in electrophysiology and microscopy that led to our current understanding of synaptic transmission. Part 2: Recycling Synaptic Vesicles: Ultrafast Endocytosis: Two mechanisms exist for recycling synaptic vesicles: clathrin-mediated and ultrafast endocytosis. Jorgensen explains why we need both. Talk summary: In his first talk, Dr. Jorgensen describes the historic experiments leading to our current understanding of synaptic transmission. In the 1950s, Sir Bernard Katz proposed that stimulation of a neuron caused synaptic vesicles to fuse with the plasma membrane and release neurotransmitter. Two decades later, John Heuser and Tom Reese produced stunning electron micrographs proving that Katz’ theory was right. In addition, Heuser and Reese made that surprising finding that just 30 sec after nerve stimulation, synaptic vesicles are recycled via clathrin-mediated endocytosis. Part 2 of Jorgensen’s talk focuses on work from his lab showing that there is a second mechanism for recycling synaptic vesicles which he calls ultrafast endocytosis. Ultrafast endocytosis occurs 1000x faster that the clathrin-mediated endocytosis identified by Heuser and Reese. Using electron microscopy, Jorgensen and his colleagues found that non-clathrin mediated endocytosis begins so rapidly after stimulation that it overlaps in time with synaptic vesicle exocytosis! Jorgensen goes on to explain why two mechanisms for recycling synaptic vesicles are necessary in vivo. Speaker Biography: Erik Jorgensen is a Distinguished Professor of Biology and a member of the Program in Neuroscience at the University of Utah, and an Investigator of the Howard Hughes Medical Institute. His lab studies the molecular mechanisms of synaptic transmission with a focus on synaptic vesicle fusion and recycling. Jorgensen’s lab uses genetics, biochemistry, light and electron microscopy to investigate neurotransmission, primarily in C. elegans. Jorgensen has been honored with the Utah Governor’s Medal for Science and Technology, a Humboldt Research Award from the Humboldt Foundation and he was one of the inaugural recipients of the F.R. Lillie Research Innovation Award from the Marine Biological Laboratory and the University of Chicago. Jorgensen has also received several awards for excellence in teaching from the University of Utah. Jorgensen received his BS from the University of California, Berkeley and his PhD from the University of Washington. He was a postdoctoral fellow in the lab of H. Robert Horvitz at the Massachusetts Institute of Technology. Learn more about Jorgensen’s research here http://biologylabs.utah.edu/jorgensen... or here http://www.hhmi.org/scientists/erik-m...