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Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this lecture, Professor Zach Murphy will discuss the liver’s central role in metabolism, protein synthesis, and nutrient storage. We begin by exploring the liver’s metabolic pathways, including carbohydrate metabolism through glycogenesis, glycogenolysis, and gluconeogenesis. We also explore its critical involvement in lipid metabolism, such as fatty acid oxidation and synthesis, cholesterol metabolism, and lipoprotein processing. Finally, we review the liver’s role in amino acid metabolism and its connection to the urea cycle for nitrogen disposal. Next, we examine the liver’s remarkable ability to synthesize essential proteins, focusing on albumin for oncotic pressure regulation, clotting factors for hemostasis, and transport proteins such as transferrin. The discussion emphasizes how these proteins are vital for maintaining circulatory stability, immune defense, and metabolic function. Finally, we cover the liver’s function as a storage organ, detailing how it stores glycogen as an energy reserve, vitamins (A, D, B12, K), and minerals such as iron and copper. We connect these storage functions to their physiological importance, explaining how the liver mobilizes these reserves to maintain homeostasis during fasting or increased metabolic demand. This comprehensive review highlights the liver’s role as a metabolic powerhouse and central hub for maintaining systemic health. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media / ninjanerdlectures / ninjanerdlectures / ninjanerdlectures https://x.com/ninjanerdsci/ / ninja-nerd 💬 Join Our Community Discord: / discord #ninjanerd #LiverMetabolism #Gastrointestinal