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In this video, Sam Markle, a clinical pharmacist, explores the controversies surrounding ACLS pharmacotherapy and dives deep into the utility of common interventions used in ACLS. With a focus on evidence-based practices, this video provides a comprehensive overview of the current state of knowledge on ACLS pharmacotherapy. Sam Markle begins by reviewing the evidence supporting epinephrine in ACLS and comparing it with vasopressin. He discusses the benefits and limitations of each medication and their effectiveness in cardiac arrest situations. The video then delves into the controversial role of the combination of vasopressin, steroids, and epinephrine (VSE) in cardiac arrest, examining the evidence and weighing the pros and cons of their use. Finally, Sam Markle compares outcomes between amiodarone and lidocaine in shockable arrest, discussing the evidence and controversies around these medications and their respective effectiveness. 0:00 - Intro 6:30 - Epinephrine in ACLS 17:40 - Vasopressin in ACLS 24:54 - Controversial Role of Vasopressin, Steroids, and epinephrine in Cardiac Arrest 35.04 - Comparing Amiodarone and Lidocaine Outcomes in Shockable Arrest 46:06 - Conclusion & Final Thoughts 50:17: Questions and Answrs #ACLS #Pharmacotherapy #CardiacArrest #EmergencyMedicine #ClinicalPharmacist #EvidenceBasedMedicine #Epinephrine #Vasopressin #Steroids #VSE #Amiodarone #Lidocain