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Resonance Effects on Acidity

In this video we are going to break down how the acidity of molecules is impacted by the resonance stabilization of their conjugate anion. We are going to look at the distribution of negative charge across multiple atoms leads to a more stable anion, especially when delocalized to a strongly electronegative atom. We will also consider the specific case of substituted phenols and how the position of electron withdrawing groups can impact the acidity profile. next, we look at nitrogen and carbon acids and how resonance stabilization impacts those species. Finally, we look at some more complicated molecules which balance resonance and inductive effects and rank their acidities. TIMESTAMPS 00:00 Intro 00:33 Resonance Stabilization of Anion Charge Density 05:23 Substituted Phenol Activity 08:59 Resonance and Non-Oxygen Bound Protons 12:05 Some More Complex Examples 20:04 End