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Complete androgen insensitivity syndrome, or CAIS, is a sex development condition which affects people with a 46,XY karyotype. Because those with CAIS have an active SRY gene, they develop internal testes, but because their bodies do not respond to the sex hormone known as androgen, affected individuals are usually born with a female phenotype. If you want to help improve medical research and psychological support for individuals with these conditions, you can donate to DSDFamilies (https://dsdfamilies.org/donate). Biology of DSDs playlist: • Disorders of Sex Development Transcripts, sources, and membership at: https://www.theparadoxinstitute.com/p... References and additional reading: [1] NIH. (2020). Androgen insensitivity syndrome. Genetics Home Reference, National Library of Medicine. [2] Oakes, M., et al. (2008). Complete androgen insensitivity syndrome--a review. Journal of Pediatric and Adolescent Gynecology, 21(6). [3] Gottlieb, B., et al. (2017). Androgen Insensitivity Syndrome, Gene Reviews (NIH). [4] Pizzo, A., et al. (2013). CAIS, a rare case of DSD. Case Reports in Obstetrics and Gynecology. [5] Pritsini, F., et al. (2017). Psychological aspects of AIS. Case Reports in Endocrinology. AIS support group: https://www.aisdsd.org