How Quinine Fights Malaria, and How That Caused* World War One скачать в хорошем качестве

How Quinine Fights Malaria, and How That Caused* World War One

Can a medicine cause a war? When chemists isolated a new compound from the bark of a South American tree, they had no idea they were changing world history, and cocktails, forever. If we look at how the bark of the cinchona tree is used to treat malaria, we can see cutting edge chemistry showing quinine binding to an enzyme that is essential for the malaria parasite’s survival. But if we look from another angle, we can see how that coincidental affinity may have been a major contributing factor to World War One. #malaria #medicinalchemistry #history Check out the new shows on PBS Terra: Why Am I Like This:    • How Did We Evolve a Sense of Smell?   Far Out:    • What Is a Water Utopia and How Can We...   You might also like: What Happens When You Distill Whiskey?    • How is Whiskey Made? A Deeper Dive In...   The Science of Maple Syrup Production:    • How Do They Make Maple Syrup?   How Lead (Maybe?) Caused the Downfall of the Roman Empire:    • How Lead (Maybe?) Caused the Downfall...   What Exactly Happened at Chernobyl?    • What Exactly Happened at Chernobyl?   The Science of Kombucha    • The Science of Kombucha   Credits: Executive Producers: Matthew Radcliff Producers: Elaine Seward Andrew Sobey Darren Weaver Writer/Host: Sophia Roberts Scientific Consultants: Selasi Dankwa, PhD Leila Duman, PhD Brianne Raccor, PhD James Webb, PhD Executive in Charge for PBS: Maribel Lopez Director of Programming for PBS: Gabrielle Ewing Reactions is a production of the American Chemical Society. © 2022 American Chemical Society. All rights reserved. Sources and more information: Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay https://pubmed.ncbi.nlm.nih.gov/30602... Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay https://www.science.org/doi/10.1126/s... The cellular thermal shift assay for evaluating drug target interactions in cells https://www.nature.com/articles/nprot... Population genetic analysis of the DARC locus (Duffy) reveals adaptation from standing variation associated with malaria resistance in humans https://www.ncbi.nlm.nih.gov/pmc/arti... Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria https://www.nature.com/articles/s4159... Plasmodium falciparum purine nucleoside phosphorylase is critical for viability of malaria parasites https://pubmed.ncbi.nlm.nih.gov/18957... Types of Malaria Parasites https://stanfordhealthcare.org/medica... Historical Review: Problematic Malaria Prophylaxis with Quinine https://www.ncbi.nlm.nih.gov/pmc/arti... Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria https://www.ncbi.nlm.nih.gov/pmc/arti... Mortality among European settlers in pre-colonial West Africa: The “White Man’s Grave” revisited https://gupea.ub.gu.se/handle/2077/49666 Malaria’s Impact Worldwide https://www.cdc.gov/malaria/malaria_w... Portrait of a serial killer https://www.nature.com/articles/news0... Antimalarial Drug Discovery: From Quinine to the Dream of Eradication https://pubs.acs.org/doi/10.1021/ml40... Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial https://www.sciencedirect.com/science... Quinine's Target https://www.science.org/content/blog-... Quinine fever https://www.nature.com/articles/s4155... Hemoglobin degradation in malaria-infected erythrocytes determined from live cell magnetophoresis https://www.ncbi.nlm.nih.gov/pmc/arti... Dramatic evolution within human genome may have been caused by malaria parasite https://www.science.org/content/artic... German Empire https://www.britannica.com/place/Germ... Berlin 1884: Remembering the conference that divided Africa https://www.aljazeera.com/opinions/20...