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This is a brief video on cancers of the two predominant cancers of the stomach: adenocarcinoma and gastric lymphoma (MALToma) This presentation was created in Google Slides Figures were created or adapted from Wikimedia Commons ADDITIONAL TAGS: Stomach cancer Adenocarcinoma Epi: Rare in USA, most are diagnosed in East Asia (China, Japan, S Korea); E Europe; Andean region of S America Risk: salt preservatives (nitroso compounds); H pylori infxn; gastrinoma; smoking; alcohol; atrophic gastritis Sx: early satiety, weight loss, mid-epigastric pain worsens with eating; bowel obstruction Dx: endoscopy + biopsy. PET-CT to stage (check liver) Poor prognosis Tx: surgical removal if early stage. Palliative if advanced stage. Gastric lymphoma (MALToma): Pathophys: chronic inflammation from H pylori infxn stimulates antigen-dependant B and T cells in gastric lamina → monoclonal B cells no longer depend on normal stimulatory pathways Dx: endoscopy + biopsy Better prognosis than adenoCa Tx: treating H pylori (quadruple treats the cancer. Triple therapy: clarithromycin, amoxicillin, and a PPI. Quad therapy: metronidazole, tetracycline, H2 blocker, bismuth. More advanced disease might require radiation, immunotherapy (rituximab), single-agent chemo By Mikael Häggström, M.D.- Author info- Reusing images- Conflicts of interest:NoneMikael Häggström - Own work, CC0, https://commons.wikimedia.org/w/index... “Suspicious” ulcer biopsied and diagnosed as adenocarcinoma, subsequently excised. By http://web2.airmail.net/uthman/specim..., Public Domain, https://commons.wikimedia.org/w/index...