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Experts from across Europe gathered at the 10th Zurich Immuno-Oncology Symposium to discuss the latest advances in cancer immunotherapy, from checkpoint inhibition and immune engagers to next-generation CAR-T strategies and tumour microenvironment research. 00:00 – 04:00: Tobias Weiss and Andreas Wicki: Welcome and Introduction 04:00 – 30:05: Sérgio Quezada: Identification of a novel checkpoint for tumour immunogenicity 30:05 – 54:40: Lukas Flatz: When self-reactivity becomes protective: autoimmunity and tumor control under checkpoint inhibitors 54:40 – 01:20:23: Caroline Robert: Current and future immune checkpoint inhibitor strategies: Combinations and novel targets 01:20:23 – 01:23:46: Surender Surender: Immune Microenvironment Modulation in Experimental Glioma by Combining CDK4/6 Inhibition with PD-1 Blockade 01:23:46 – 01:26:26 André Rosa: Immunocompetent Cancer-on-Chip Models to Assess Safety and Efficacy of New Drug Modalities 01:26:26 – 01:51:31: Peter Ellmark: Reprogramming tumor-associated macrophages 01:51:31 – 01:54:41: Sheila Dakhel Plaza: Combinatorial treatment with small molecule inhibitors abrogates systemic toxicity of tumor-targeted cytokine fusion protein 01:54:41 – 01:58:36: Michael A. Schmid: PRO-XTEN masked T cell engagers enabling protease-specific activation only in the tumor microenvironment 01:58:36 – 02:23:50: Magnus Essand: Optimising CAR-T cells for improved efficacy and reduced toxicity 02:23:50 – 02:50:15: Christian Buchholz: Current and future concepts of in vivo engineered CAR immune cells 02:50:15 – 03:12:00: Sonia Tugues: Lymphocyte Networks Orchestrating Colorectal Cancer Liver Metastases 03:12:00 – 03:14:39: Violetta Gogoleva: Ms4a7+ Monocyte-Derived Macrophages in Tumor Immunity