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IGV Tutorial Part 5: Structural Variants

In this final video of an IGV tutorial series for beginners, I cover how to interpret structural variants. First foundations: how reads are generated during sequencing, and how IGV handles reads that contain various types of structural variants. IGV demonstration begins at 13:42 and covers the following tools: viewing soft clipped bases, coloring by insert size and read orientation, region navigator, BLAT, finding motif, and viewing pairs in split screen. Previous videos cover basic IGV tools and should be viewed first. Video 1: Introduction, downloading and installing IGV Video 2: File types that can be used in IGV, viewing DNA alignments Video 3: Basic layout and software tools for DNA alignment viewing/analysis Video 4: Viewing SNPs and indels, distinguishing true variants from artifacts Video 5: Viewing/interpreting structural variants IGV stands for "Integrated Genomics Viewer," and is an open source software for viewing various types of genomic data. In this tutorial series we look at Next Generation Sequencing data produced by a gene panel designed to identify mutations that could be clinically relevant to cancer identification and treatment.