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#23349

Nerve Sparing Radical Prostatectomy in High-Risk Prostate Cancer Patients is feasible with Good Functional Results without impairing Oncological Outcomes: A Longitudinal Long-Term Single Centre Study Soliman C1, Furrer M1 1. The Royal Melbourne Hospital KEYWORDS: Surgery, Incontinence, Sensory Dysfunction High-risk prostate cancer is associated with a higher incidence of extraprostatic disease. This concept has led to an aversion of nerve-sparing (NS) procedures to prevent positive surgical margins as they may increase risk of cancer-recurrence. Due to concerns of anticipated inferior oncological and functional outcomes radical prostatectomy (RP) has not commonly been offered to men with high-risk prostate cancer. Several studies have addressed the impact of NS on urinary continence (UC) and erectile function recovery (EFR). A systematic review and meta-analysis recently published(1) reports NS to be associated to better functional outcomes, while some authors failed to report such association(2,3). However, comparison of functional results in high risk prostate cancer patients is difficult as data on UC and EFR after RP in these patients remains scarce. Little is known about outcomes stratified by degree of NS. Whether NS RP should be attempted in these patients is controversial and remains a matter of debate. The aim of this study was to assess outcomes in high-risk prostate cancer patients following RP.