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Sickle Cell Disease is an inherited blood disorder that causes the bone marrow to produce red blood cells with defective hemoglobin. Leg ulcers are a common complication of sickle cell disease. Sickle cell leg ulcers appear either spontaneously or as a result of local trauma, and they often persist for a long time. Sickle cell ulcers usually begin as small, elevating crusting sores on the lower third of the leg. They can be single or multiple. Some heal rapidly, but others persist for years or heal, but then recur in the same area of scar tissue. The periwound tissue may present with hyperpigmentation and loss of subcutaneous fat and hair follicles. these ulcers can be very painful, and they are often accompanied by infection. Because of their common presentation, sickle cell ulcers are commonly mistaken for venous insufficiency ulcers. To learn more about wound care, take one of our wound care courses: https://woundeducators.com/wound-care... To learn more about sickle cell disease: https://woundeducators.com/an-introdu... https://woundeducators.com/sickle-cel... https://woundeducators.com/management... https://woundeducators.com/sickle-cel...