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Rhabdomyolysis: Pathophysiology

In this video we explain the pathophysiology of Rhabdomyolysis. We use simple explanations and diagrams that are easy to understand, aimed at helping medical students and healthcare professionals of all levels. Timestamps: 00:55 - Anatomy & Physiology 07:04 - Pathophysiology 14:51 - Summary Rhabdomyolysis is a clinical syndrome where there is a sudden and excessive breakdown of muscle fibre. This breakdown causes the release of the intracellular components of the muscle cell to enter general circulation. Excessive muscle breakdown is caused by either direct muscle injury or inadequate energy supply to the muscle cell. Muscle cell injury or energy depletion results is an excessive breakdown of the cell, leading to an intracellular influx of sodium and calcium. This causes sustained myofibril contraction, damage to the cytoskeleton of the muscle cell and rupture of the cellular membrane. Causes can either be traumatic or non-traumatic and symptoms can range from ranges from an asymptomatic illness to a life threatening condition. Thank you for watching and I hope you found this video helpful, be sure to check out our video on the signs, symptoms, investigations, diagnosis and management of rhabdomyolysis, and if there are any topics you would like us to cover then please leave a comment in the comment section below. We really appreciate your feedback as it helps us to design better quality videos. Click the link to show Animated Medicine your support and buy them a coffee: https://www.buymeacoffee.com/AnimatedMed Although this video is designed to provide education, it should not be used to guide clinical practice, treatment or medical decision making. These videos are designed to provide a detailed overview of each topic, and although a lot of research goes into each video errors can occur and medical practice, medical information and protocols may change over time, which is why it is important to follow local and national guidelines. These videos do not constitute medical advice, medical advice should be obtained from an appropriate healthcare provider or senior clinician.