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Amir Fathi, MD, MPH, Massachusetts General Hospital, Boston, MA, discusses the promising results of the KOMET-001 trial (NCT04067336), which evaluated the menin inhibitor ziftomenib in patients with NPM1-mutated or KMT2A-rearranged relapsed/refractory (R/R) acute myeloid leukemia (AML). Dr Fathi highlights that the compound has demonstrated activity in patients who are traditionally more resistant to treatment, such as those who have progressed on venetoclax or have relapsed following transplant. This agent is also being explored in combination studies. This interview took place at the 13th Annual Meeting of the Society of Hematologic Oncology (SOHO 2025) in Houston, TX. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.