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Hanny Al-Samkari, MD, Massachusetts General Hospital, Boston, MA, shares some insights into the challenges of managing patients with persistent isolated mild thrombocytopenia (PIMT), which may increase an individual's risk of developing immune thrombocytopenia (ITP) and other hematological malignancies. Dr Al-Samkari also discusses the development of a novel clinical guidance statement, which aims to guide clinicians and provide further information on how to manage these patients in clinical practice. This interview took place at the 31st Congress of the International Society on Thrombosis and Haemostasis (ISTH), held in Montréal, Canada. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.