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Summary In episode 9, Drs. Grant and Ziva Cooper discuss her research on medicinal cannabis, focusing on gender differences in cannabis response, the therapeutic potential of minor cannabinoids and terpenes, and the opioid-sparing effects of cannabinoids. The conversation highlights the complexities of cannabis research, including regulatory challenges and the need for further studies to clarify the role of cannabinoids in medicine. Takeaways • Dr. Ziva Cooper is a leading researcher in medicinal cannabis. • Gender differences in cannabis response are significant. • Women may be more sensitive to the pain-relieving effects of cannabis. • Minor cannabinoids like CBG show promise for therapeutic use. • Terpenes may enhance the effects of THC without psychoactivity. • Cannabinoids could potentially reduce opioid use in chronic pain patients. • Research on cannabinoids faces significant regulatory hurdles. • Understanding the psychological aspects of pain is crucial. • The therapeutic potential of cannabinoids is still being explored. • Future research is needed to clarify the role of cannabinoids in medicine. Chapters 00:00 CBG for Pain and Appetite Stimulation 00:51 Exploring Sex Differences in Cannabis Response 00:52 Intro 01:24 Understanding Cannabinoids: THC, CBD, and Beyond 01:24 Introduction to Ziva Cooper, PhD 02:17 THC and Sex and Gender Differences 11:09 Minor Cannabinoids, Terpenes and Terpenoids 13:46 Cannabigerol (CBG) for Pain and Appetite Stimulation 20:21 Cannabichromine for Pain 21:48 Exploring Cannabichromine (CBC) and Its Potential 22:21 Understanding Terpenes and Terpendoids (Myrcene and Beta-Caryophyllene) 24:46 The Different Regulatory Status of Terpenes and Terpenoids 26:04 Cannabinoids as Opioid-Sparing Agents 30:22 Cannabinoids and Substance Use Disorders 32:04 The Psychological Experience of Pain 35:14 Advancing Cannabinoid Research in Medicine 38:10 Regulatory Hurdles to Researching Cannabis and Cannabinoids 40:16 Outro