New Drug - Seviteronel can 'switch' aggressive cancer cells скачать в хорошем качестве

New Drug - Seviteronel can 'switch' aggressive cancer cells

This animation represents cancer cells dividing out of control and shows one cancer-associated molecule; androgen receptor that contributes to the aggressive state of some cancer cells. Associate Professor Christine Chaffer is leading research that investigates how a new drug called Seviteronel may switch cells out of this aggressive state and render them sensitive to chemotherapy again. Animation and VO by Dr Kate Patterson, Garvan Institute. Animation made with Autodesk Maya, Molecular Maya and compositing with Adobe After Effects. Narration: Our organs and tissues are made up of healthy cells that exist in an organised but delicate balance. Cancer occurs when some of these cells start to divide out of control, in many cases multiplying into a tumour and impacting on the surrounding healthy tissue. Chemotherapy, is often used to eradicate cancer but it is less effective on cancer cells that are naturally more aggressive. In some cancers, the chemotherapy itself can drive the emergence of resistant cancer cells. We discovered that inside these aggressive cells, androgen signalling is required for the cancer cells to transform into a resistant state. In normal cells, the androgen receptor is activated by hormones that bind to the receptor which then controls the appropriate growth and development of the cell. In aggressive cancer cells, the androgen receptor is extremely abundant and highly active, which contributes to the aggressive state of the cell. A new drug called seviteronel can switch cells out of this aggressive state by blocking the hormones that activate the androgen receptor. This makes cells sensitive to chemotherapy again. Using Sevi in a combination treatment approach may improve the effectiveness of chemotherapy and, ultimately, improve outcomes for patients.