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Ilana Cass, MD, Dartmouth-Hitchcock Medical Center, Lebanon, NH, comments on the evolving landscape of endometrial cancer treatment, highlighting the shift from relying solely on microscopic classification to molecular characterization, which enables personalized therapy and more effective treatment strategies. The potential benefits of de-escalating therapies, shortening treatment duration, and omitting chemotherapy, which could significantly improve the risk-benefit ratio for patients, are additionally discussed. This approach, informed by advances in molecular drivers of cancer, holds promise for improving outcomes in endometrial cancer and other solid tumors. This interview took place at 2025 European Society for Medical Oncology (ESMO) Gynaecological Cancers Congress in Vienna, Austria. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.