Topic (55) Antifungal Agents = SAR of Anti Fungal Agents | Antifungal Agents | Medicinal Chemistry скачать в хорошем качестве

Topic (55) Antifungal Agents = SAR of Anti Fungal Agents | Antifungal Agents | Medicinal Chemistry

Download the "Solution Pharmacy" Mobile App to Get All Uploaded Notes, Model Question Papers, Answer Papers, Online Tests and other GPAT Materials - https://play.google.com/store/apps/de... Contents for Unit 04 of Medicinal Chemistry 03 Antifungal agents: Antifungal antibiotics: Amphotericin-B, Nystatin, Natamycin, Griseofulvin. Synthetic Antifungal agents: Clotrimazole, Econazole, Butoconazole, Oxiconazole Tioconozole, Miconazole*, Ketoconazole, Terconazole, Itraconazole, Fluconazole, Naftifine hydrochloride, Tolnaftate*. Anti-protozoal Agents: Metronidazole*, Tinidazole, Ornidazole, Diloxanide,Iodoquinol, Pentamidine Isethionate, Atovaquone, Eflornithine. Anthelmintics: Diethylcarbamazine citrate*, Thiabendazole, Mebendazole*, Albendazole, Niclosamide, Oxamniquine, Praziquantel, Ivermectin. Sulphonamides and Sulfones Historical development, chemistry, classification and SAR of Sulfonamides: Sulphamethizole, Sulfisoxazole, Sulphamethizine, Sulfacetamide*, Sulphapyridine, Sulfamethoxazole*, Sulphadiazine, Mefenide acetate, Sulfasalazine. Folate reductase inhibitors: Trimethoprim*, Cotrimoxazole. Sulfones: Dapsone*. Anti Fungal Agents These are drugs used for superficial and deep (systemic) fungal infections. Many topical antifungals have been available since the antiseptic era. Two important antibiotics: amphotericin B to deal with systemic mycosis, and griseofulvin—to supplement attack on dermatophytes were introduced around 1960. Antifungal property of flucytosine was noted in 1970, but it could serve only as a companion drug to amphotericin. CLASSIFICATION Classification Based on the Chemical Structure, Action, and Source The antifungal agents can be divided into the following classes, based on their chemical structure, mechanism of action, and source: I. Antibiotics: Amphotericin B, Nystatin, Griseofulvin II. Azoles (imidazole, triazole derivates) Triazoles—Fluconazole, Itraconzole, Terconazole Imidazoles—Clotrimazole, Ketoconazole, Miconazole, Bifonazole, Butoconazole, and Zinoconazole III. Fluorinated pyrimidines: Flucytosine IV. Chitin synthetase inhibitors: Nikomycin Z V. Peptides/proteins: Cispentacin VI. Miscellaneous: Ciclopirox, Tolnaftate, Naftifine, and Terbinafine Classification Based on the Route of Administration I. Drugs for subcutaneous and systemic mycoses: Amphotericin B, Fluconazole, Flucytosine, Itraconazole, Ketoconazole. II. Drugs for superficial mycoses: Clotrimazole, Econazole, Griseofluvin, Miconazole, Nystatin. Get in touch with the solution by just clicking the following links- Facebook Group-   / solutionpharamcy   Mobile App - https://play.google.com/store/apps/de... New Channel (Pharmacy Dictionary)    / @pharmacydictionary   E-Mail for official and other work - [email protected] #solutionpharmacy #Pharmacologyclass #Pharmacognosyvideos #GPAT